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KMID : 0361020000430090967
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Korean Journal of Otolaryngology - Head and Neck Surgery
2000 Volume.43 No. 9 p.967 ~ p.971
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The Relationship between Expression of E-Cadherin, Clinical Staging and Differentiation in Squamous Cell Carciomas of Head and Neck
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Koo Young-Ah
Na Kyoung-Sup
Park Myoung-Geun
Han Kwang-Sik
Park Young-Min
Shim Jung-Won
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Abstract
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Background and Objectives: In recent years, much attention has been directed towards cell adhesion molecules. This study was designed to confirm the significance of E-cadherin as a maker for differentiation and invasiveness of squamous cell carcinomas of the head and neck.
Materials and Methods: Twenty-nine patients with squamous cell carcioma of the head and neck were used in this study. The specimens of formalin-fixed paraffin-embedded tissues were investigated by immunohistochemical analysis using monoclonal anti-E-cadherin antibody.
Results: The results showed that there was a statistically significant correlation in the head and neck squamous cell carcinoma between the T and the N stage and the expression E-cadherin (p=0.025, p=0.015). The cell differentiation was also correlated with the reduction of E-cadherin(p=0.005).
Conclusion: E-cadherin may be linked to progression and differentiation of the head and neck squamous cell carcinoma. E-cadherin immunostaining in the primary tumor appear to be a good marker for the invasiveness and the metastasis of tumors.
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KEYWORD
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E-cadherin, Head and neck cancer
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